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Ischaemic Stroke and Combined Oral Contraceptives:Results of an International, Multicentre, Case-Control Study
Lancet 348:498-505, Poulter,N.R.,et al, 1996
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Article Abstract
The association between use of oral contraceptives(OCs)and cerebral infarction was established in studies from northern Europe and the USA during the 1960s and 1970s.Since then,the constituents of hormonal OCs have changed and now contain lower doses of oestrogen and progestagen. Current recommendations restrict OC use to younger women who do not have other risk factors for cardiovascular disease.In this international study we assessed the risk of OC-associated first stroke in women from Europe and other countries throughout the world.The incidence of ischaemic stroke is low in women of reproductive age and any risk attributable to OC use is small.The risk can be further reduced if users are younger than 35 years, do not smoke,do not have a history of hypertension,and have blood pressure measured before the start of OC use.In such women OC preparations with low oestrogen doses may be associated with even lower risk.
 
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cerebrovascular accident
cerebrovascular accident,women
oral contraceptives
oral contraceptives,cerbrovascular disease and
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